Protective Effect of Mirabilis Jalapa Leaves on Anti-tubercular Drugs Induced Hepatotoxicity

Objectives: The present study was undertaken for investigating the protective effect of ethanolic extract of Mirabilis Jalapa Linn leaves on antitubercular drugs induced hepatotoxicity. Methods: Anti-tubercular drugs were used to induce hepatotoxicity in rats. Silymarin was used as standard drug (100 mg/kg p.o.). Ethanolic extract of leaves of Mirabilis Jalapa Linn (250 & 500 mg/kg p.o.) was administered along with one hour prior administration of anti-tubercular drugs once daily for 35 days. Results: Liver biomarkers such as SGOT, SGPT, ALP, TB, total cholesterol were elevated and total HDL were reduced on anti-tubercular drugs administration. The treatment of ethanolic extract of Mirabilis Jalapa Linn leaves 250 mg/kg and 500 mg/kg with anti-tubercular drugs were significantly reduced liver biomarker enzymes. Antioxidant parameters such as SOD, CAT, GSH, GPx and GRx were suppressed and increased TBARs levels in anti-tubercular drugs administration but restored these antioxidant levels in the treatment of ethanolic extract of Mirabilis Jalapa Linn leaves at a dose of 250 mg/kg and 500 mg/kg. Conclusion: The result of the present study was indicated that Mirabilis Jalapa Linn leaves showed protective effect on hepatotoxicity induced by anti-